Disorder of the personality: a possible factor of risk for the dementia.

OBJECTIVES: The fact that more and more people suffer from dementia makes it very important to know the different risk factors to prevent their appearance. The objective of this article is to study personality disorder as a possible risk factor for the onset of an insane process, and to relate personality disorders of Cluster B and dementia. METHODOLOGY: A systematic review and meta-analysis was carried out with scientific literature published up to 2015. RESULTS: Twelve of the articles that we found met the specified criteria of selection and quality and study the relationship between a personality disorder and the emergence of a dementia. Although with the studies made so far it can't be concluded that the first one is a risk factor for the second one, it has been noted, thanks to neuroimaging techniques, that patients with Cluster B personality disorders develop alterations in brain structures (in the prefrontal, temporal and parietal cortex, as well as an alteration in the NAA levels and the grey matter levels) and which are also involved in a demented process. CONCLUSIONS: Definitely, the patients with medical record of the borderline or narcissistic personality disorder present more alterations in the brain structures mentioned, such that presenting these types of personality disorders could increase the risk of developing dementia in the future.

Trastorno de la personalidad: un posible factor de riesgo para la demencia / Disorder of the personality: a possible factor of risk for the dementia

Objetivos. El hecho de que cada vez haya más personas que padezcan demencia hace que sea muy importante conocer los diferentes factores de riesgo para prevenir su aparición. El objetivo de este artículo es estudiar el trastorno de la personalidad como posible factor de riesgo para la aparición de un proceso demencial, y relacionar trastornos de la personalidad del Clúster B y demencia. Metodología. Se realizó una revisión sistemática y metaanálisis con literatura científica publicada hasta el año 2015. Resultados. Doce de los artículos que se encontraron cumplían con los criterios de selección y calidad especificados y estudian la relación entre un trastorno de personalidad y la aparición de una demencia. Aunque con los estudios hechos hasta el momento no se puede concluir que el primero sea un factor de riesgo para el segundo, sí que se ha podido observar, mediante técnicas de neuroimagen, que los pacientes con trastornos de personalidad del Clúster B desarrollan alteraciones en estructuras cerebrales (en la corteza prefrontal, temporal y/o parietal, además de una alteración en los niveles de N-acetil Aspartato y de sustancia gris) que también están implicadas en un proceso demencial. Conclusiones. En definitiva, los pacientes con historia clínica de trastorno límite o trastorno narcisista de la personalidad presentan más alteraciones en las estructuras cerebrales mencionadas, de tal manera que presentar este tipo de trastornos de la personalidad podría aumentar el riesgo de padecer demencia en un futuro

Objectives. The fact that more and more people suffer from dementia makes it very important to know the different risk factors to prevent their appearance. The objective of this article is to study personality disorder as a possible risk factor for the onset of an insane process, and to relate personality disorders of Cluster B and dementia. Methodology. A systematic review and meta-analysis was carried out with scientific literature published up to 2015. Results. Twelve of the articles that we found met the specified criteria of selection and quality and study the relationship between a personality disorder and the emergence of a dementia. Although with the studies made so far it can’t be concluded that the first one is a risk factor for the second one, it has been noted, thanks to neuroimaging techniques, that patients with Cluster B personality disorders develop alterations in brain structures (in the prefrontal, temporal and parietal cortex, as well as an alteration in the NAA levels and the grey matter levels) and which are also involved in a demented process. Conclusions. Definitely, the patients with medical record of the borderline or narcissistic personality disorder present more alterations in the brain structures mentioned, such that presenting these types of personality disorders could increase the risk of developing dementia in the future